Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

General description

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis.

Potent β-lactamase-resistant antibiotic of cephalosporin class. Active against gram-positive and gram-negative organisms, including gram-negative anaerobes. Inhibits cell wall synthesis. Has an optimal pH of 4.5-6.5.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Molinari, G., et al. 1991. J. Chemotherap. 3, 6.Vallee, F., and LeBel, M. 1991. Antimicrob. Agents Chemother. 35, 2057.

Packaging

2 g in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 10 days at 4°C or for up to 13 weeks at -20°C.

Warning

Toxicity: Standard Handling (A)